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Index > Protein center > Vps29(Gene name) > Mouse
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  • Vps29 (Gene name),
  • Vacuolar protein sorting-associated protein 29 (Protein name ),  VPS29_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Vps29;
    Protein name:
    Vacuolar protein sorting-associated protein 29;
    Alternative:
    Vesicle protein sorting 29;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN (By similarity). Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2.
    Function:
    Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro).
    Subcellular Location:
    Cytoplasm Membrane Peripheral membrane protein Endosome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    182
    Sequence:
    50:
    MLVLVLGDLH | IPHRCNSLPA | KFKKLLVPGK | IQHILCTGNL | CTKESYDYLK | 
    100:
    TLAGDVHIVR | GDFDENLNYP | EQKVVTVGQF | KIGLIHGHQV | IPWGDMASLA | 
    150:
    LLQRQFDVDI | LISGHTHKFE | AFEHENKFYI | NPGSATGAYN | ALETNIIPSF | 
    182:
    VLMDIQASTV | VTYVYQLIGD | DVKVERIEYK | KS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    E5165h
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    ELISA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    ELISA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    ELISA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    ELISA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    E5165b
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    Packing:
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    CLIA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    U5165c
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    CLIA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    U5165h
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    Packing:
    96T
    CLIA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    U5165m
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    Packing:
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    CLIA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    U5165b
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    MSDS:
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    Packing:
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    CLIA Kit for Mouse Vacuolar protein sorting-associated protein 29
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    Packing:
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    Polyclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
    Polyclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
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    P5165Rb-m
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    Polyclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
    Polyclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
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    P5165Rb-h
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    Polyclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
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    P5165Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
    Monoclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
    Monoclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
    Monoclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
    Monoclonal Antibody for Mouse Vacuolar protein sorting-associated protein 29
    Protein for Mouse Vacuolar protein sorting-associated protein 29
    Protein for Mouse Vacuolar protein sorting-associated protein 29
    Protein for Mouse Vacuolar protein sorting-associated protein 29
    Protein for Mouse Vacuolar protein sorting-associated protein 29
    Protein for Mouse Vacuolar protein sorting-associated protein 29

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface."
      Hesketh G.G. , Perez-Dorado I. , Jackson L.P. , Wartosch L. , Schafer I.B. , Gray S.R. , McCoy A.J. , Zeldin O.B. , Garman E.F. , Harbour M.E. , Evans P.R. , Seaman M.N. , Luzio J.P. , Owen D.J.
      Dev. Cell29:591-606(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANKRD27;MUTAGENESIS OF LEU-152
    2. 2.
      "Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly."
      Collins B.M. , Skinner C.F. , Watson P.J. , Seaman M.N. , Owen D.J.
      Nat. Struct. Mol. Biol.12:594-602(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH MANGANESE IONS;ABSENCE OF CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;SUBUNIT;MUTAGENESIS OF ASN-39; VAL-90 AND ILE-91
    3. 3.
      "Molecular cloning of mouse vacuolar sorting protein VPS29."
      Edgar A.J.
      Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lung.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Bone marrow.
      tissue: Embryo.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Mammary tumor.
    6. 6.
      Lubec G. , Klug S.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-14;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Hippocampus.
    7. 7.
      "Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking."
      Kim E. , Lee Y. , Lee H.J. , Kim J.S. , Song B.S. , Huh J.W. , Lee S.R. , Kim S.U. , Kim S.H. , Hong Y. , Shim I. , Chang K.T.
      Biochem. Biophys. Res. Commun.403:167-171(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    8. 8.
      "VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins."
      Swarbrick J.D. , Shaw D.J. , Chhabra S. , Ghai R. , Valkov E. , Norwood S.J. , Seaman M.N. , Collins B.M.
      PLoS ONE6:E20420-E20420(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;LACK OF PHOSPHATASE ACTIVITY;INTERACTION WITH SNX1
    9. 9.
      "Assembly and solution structure of the core retromer protein complex."
      Norwood S.J. , Shaw D.J. , Cowieson N.P. , Owen D.J. , Teasdale R.D. , Collins B.M.
      Traffic12:56-71(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    10. 10.
      "Vps26A and Vps26B subunits define distinct retromer complexes."
      Bugarcic A. , Zhe Y. , Kerr M.C. , Griffin J. , Collins B.M. , Teasdale R.D.
      Traffic12:1759-1773(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
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